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Buy L Arginine Injections


Arginine, also known as L-arginine, is an amino acid. Amino acids are the building blocks of proteins. Arginine is produced naturally in the body. It is also found in foods such as red meat, poultry, fish, dairy products, eggs, and seeds of all types. Arginine helps to dilate or open, blood vessels. It works by converting into nitric oxide in the body. Nitric oxide then dilates the blood vessels by relaxing the muscles that constrict them. Arginine is produced pharmaceutically and given as a supplement for many conditions. It can stimulate the release of insulin, growth hormone (helps increase muscle mass and reduce the amount of fat in the body), and other substances.




buy l arginine injections



Arginine may also help with athletic performance, kidney function following a transplant, preeclampsia, inflammation in the digestive tract of premature infants, and immune system function. Topically, L-arginine helps wound healing, blood flow to cold hands and feet (helpful for those with diabetes), and sexual issues in both men and women.


Not enough is known about how it affects those who are pregnant or breastfeeding. Special precautions should be taken in those with asthma, allergies, cirrhosis, herpes, low blood pressure, recent heart attack, and kidney disease. Because blood pressure is affected while taking arginine, those who anticipate surgery should discontinue use at least 2 weeks prior to the scheduled date to avoid any complications. Children taking arginine need to be closely monitored to avoid serious side effects. Arginine can interact with several different medications, so it is important to speak with your doctor before taking.


Intracerebroventricular (I.C.V.) administration of an inhibitor of nitric oxide synthase (NOS) increases oxytocin but not vasopressin secretion, in dehydrated rats [38]. Surprisingly, central injection of L-arginine, the substrate for NOS, caused a similar effect. Kyotorphin (L-tyrosyl-L-arginine), a dipeptide formed from L-arginine by kyotorphin synthetase in the brain may mediate this magnocellular response. Therefore, the dose and time responses of hormone release were compared following I.C.V. injection of kyotorphin and L-arginine to conscious rats that were normally hydrated or deprived of water for 24 h. In water-sated rats, both L-arginine and kyotorphin increased blood pressure and plasma glucose levels coincident with elevating circulating levels of oxytocin, but not vasopressin. In dehydrated animals, both L-arginine and kyotorphin increased plasma oxytocin levels with a similar time course but only kyotorphin decreased vasopressin release. D-arginine, like L-arginine, stimulated secretion of oxytocin, indicating a nonstereospecific effect. A kyotorphin receptor antagonist (L-leucyl-L-arginine) given I.C.V. to dehydrated animals elevated plasma oxytocin and prevented the decrease in vasopressin levels after kyotorphin. Thus, kyotorphin, but not L-arginine, appears to attenuate release of vasopressin either directly from magnocellular neurons or indirectly via modulating compensatory reflexes activated by the pressor response. On the other hand, an excess of L-arginine and kyotorphin within the CNS may mimic the stress response by augmenting release of oxytocin and activating the sympathetic nervous system to increase blood pressure and plasma glucose levels.


No simple rat model for chronic pancreatitis exists at present. A single dose of arginine has recently been shown to induce acute pancreatitis in rats. This study was designed to assess whether serial injections of arginine would induce reproducible chronic pancreatic damage. Forty rats received an intra-peritoneal injection of 500 mg per 100 g body weight of L-arginine followed by three injections of 250 mg per 100 g over 10 days. The rats were killed 24 h after each injection and at intervals of up to 6 months. Serum amylase levels were increased in the acute phase only. Examination of the pancreas at 24 h showed a severe oedematous pancreatitis. By day 5 there was up to 90% acinar destruction with adipose tissue replacement, although ductal, vascular, and islet cells appeared undamaged. These changes were present 6 months after injection. This is proposed as a new, simple, and reproducible method of inducing chronic pancreatic damage in the rat.


Since L-Arginine stimulates the release of growth hormone, it may be used clinically to the detect growth hormone deficiency in various conditions (e.g., panhypopituitarism, pituitary dwarfism, pituitary trauma, inadequate growth, etc.). The amino acid has also been used to evaluate pituitary function in gigantism and acromegaly.1 Patients with compromised pituitary function who are given arginine will show less of an increase (or no increase) in growth hormone levels.8


L-Arginine is also indicated for treating high ammonia concentrations in patients with carbamyl phosphate synthetase deficiency, ornithine transcarbamylase deficiency, argininosuccinate lyase deficiency, and argininosuccinate synthetase deficiency. These enzymes are a part of the urea cycle. If they are in short supply and if L-arginine is not available, protein breakdown and ammonia build-up occurs. Therefore L-arginine administration can ameliorate these side effects.2, 3, 4


This study evaluated the influence of administering different levels of L-arginine into eggs of 0-day-old Japanese quail embryos. On day 0 of incubation, 480 eggs (120 for each treatment group) were injected with 0% arginine (C group), 1% arginine (T1), 2% arginine (T2) or 3% arginine (T3). After hatching, 336 quail chicks (84 chicks produced from each in ovo injection treatment) were placed in an experimental quail house and allocated to four treatment groups of three replicates, with 16 quail chicks for each replicate. Traits involved in this study were hatchability rate, initial body weight (7 days of age), final body weight (42 days old), feed intake, weight gain, feed conversion ratio and blood serum glucose, protein, cholesterol, total lipids, triglycerides, calcium and phosphorus concentrations, and proportional weights of the carcass, breast, legs, backbone, wings, neck, abdominal fat, liver, heart and gizzard. Results revealed that in ovo injection with different levels of L-arginine on day 0 of incubation resulted in significant increases in the hatchability rate, initial body weight, final body weight, feed conversion ratio, and blood serum glucose, protein, total protein, calcium and phosphorus concentrations, as well as the proportional weights of the carcass, breast, legs, liver, heart and gizzard. However, there was no significant difference in feed intake between treatment groups. Significant decreases were recorded in blood serum cholesterol, total lipids and triglyceride concentrations, and proportional weights of the backbone, wings and abdominal fat. In conclusion, the inoculation of different levels of L-arginine into eggs of 0-day-old quail embryos, especially at the levels of 2% and 3% arginine, resulted in a significant improvement in the productive and physiological performance of the quail. Hence in ovo injection with L-arginine could be used as a tool for enhancing the hatchability rate and productive performance of quail hatched from the egg.


Each 100 mL of R-Gene 10 (Arginine Hydrochloride Injection, USP) for intravenous use contains 10 g of L-Arginine Hydrochloride, USP in Water for Injection, USP (equivalent to a 10% solution). L-arginine is a naturally occurring amino acid.


The recommended adult dose is 30 g arginine hydrochloride(300 mL of R-Gene 10) administered by intravenous infusion over 30 minutes. Thetotal dose should not exceed 30 g arginine hydrochloride. See Directions forUse for preparation instructions.


The recommended pediatric dose is 0.5 g/kg argininehydrochloride (5 mL/kg of R-Gene 10) administered by intravenous infusion over30 minutes. The total dose should not exceed 30 g arginine hydrochloride.


The arginine in R-Gene 10 canbe metabolized resulting in nitrogen-containing products for excretion. Theeffect of an acute amino acid or nitrogen burden upon patients with impairmentof renal function should be considered when R-Gene 10 is to be administered.


It is not known whetherintravenous administration of R-Gene 10 could result in significant quantitiesof arginine in breast milk. Systemically administered amino acids are secretedinto breast milk in quantities not likely to have a deleterious effect on theinfant. Nevertheless, caution should be exercised when R-Gene 10 is to beadministered to nursing women.


Clinical studies of argininedid not include a sufficient number of subjects aged 65 and over to determinewhether they respond differently from younger subjects. Other reported clinicalexperience has not identified differences in responses between the elderly andyounger patients.


It has been known for approximately 30 years that large doses of the semi-essential basic amino acid L-arginine induce severe pancreatic inflammation in rats. Recently, it has been demonstrated that L-arginine can also induce pancreatitis in mice. Moreover, other basic amino acids like L-ornithine and L-lysine can cause exocrine pancreatic damage without affecting the endocrine parenchyma and the ducts in rats. The utilization of these noninvasive severe basic amino acid-induced pancreatitis models is becoming increasingly popular and appreciated as these models nicely reproduce most laboratory and morphological features of human pancreatitis. Consequently, the investigation of basic amino acid-induced pancreatitis may offer us a better understanding of the pathogenesis and possible treatment options of the human disease.


Close to 10 years have passed since our previous review was published on the L-arginine-induced AP model.7 Since then, this noninvasive severe necrotizing AP model has become increasingly appreciated and more thoroughly investigated. Therefore, the numerous advances in the field justify an overview of recent developments. For the most part, this review concentrates on English language publications that appeared since our previous review on L-arginine-induced AP. We will also summarize the advantages and disadvantages of using the basic amino acid-induced pancreatitis models. 041b061a72


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